Alan Aw

A 🏋🏻‍♂️ (representing “heavy lifting”) indicates (co-)first authorship. Though, science is a team effort. Maths papers are ordered alphabetically by last name.

Publications

1. 🏋🏻‍♂️ F. Zhou, A.J. Aw, D. Erdmann-Pham, J. Fischer, Y.S. Song (2025+). Robust and adaptive non-parametric tests for detecting general distributional shifts in gene expression. Cell Reports Methods (to appear). DOI: 10.1101/2025.03.06.641952 (Software: QRScore (Bioconductor,Github))
2. G. Benegas, C. Albors, A.J. Aw, C. Ye, Y.S. Song (2025). A DNA language model based on multi-species alignment predicts the effects of genome-wide variants. Nature Biotechnology. DOI: 10.1038/s41587-024-02511-w (Code and Data, VEP Scores)
3. 🏋🏻‍♂️ A.J. Aw, J.P. Spence & Y.S. Song (2024). A simple and flexible test of sample exchangeability with applications to statistical genomics. Annals of Applied Statistics 18 (1):858-881. DOI: 10.1214/23-AOAS1817 (Software: flintyR and flintyPy, Code and Data, Tutorials)
4. 🏋🏻‍♂️ A.J. Aw, L.C. Jin, N.M. Ioannidis & Y.S. Song (2023). The impact of stability considerations on genetic fine-mapping. eLife Reviewed Preprint. DOI: 10.7554/eLife.88039.1 (Shiny App, Code and Data)
5. 🏋🏻‍♂️ T.C. Zeng, A.J. Aw & M.W. Feldman (2018). Cultural hitchhiking and competition between patrilineal kin groups explain the post-Neolithic Y-chromosome bottleneck. Nature Communications 9 (1): article no. 2077. DOI: 10.1038/s41467-018-04375-6 (Code and Data)
6. A.J. Aw & N.A. Rosenberg (2018). Bounding measures of genetic similarity and diversity using majorization. Journal of Mathematical Biology 77 (3): 711-737. DOI: 10.1007/s00285-018-1226-x
7. A.J. Aw & C.Y. Ku (2015). The covering radius problem for sets of 1-factors of the complete uniform hypergraphs. Discrete Mathematics 338 (6):P 875-884. DOI: 10.1016/j.disc.2015.01.014
8. A.J. Aw (2014). The multicovering radius problem for some types of discrete structures. Designs, Codes and Cryptography 72 (2): 195-209. DOI: 10.1007/s10623-012-9755-6
9. A.J. Aw (2012). The Turán number and probabilistic combinatorics. The American Mathematical Monthly 119 (6): 510-513. DOI: 10.4169/amer.math.monthly.119.06.510

Preprints / Under Review

1. 🏋🏻‍♂️ A.J. Aw, R. Mandla, Z. Shi, Penn Medicine Biobank, B. Pasaniuc, I. Mathieson (2025+). Hidden structure in polygenic scores and the challenge of disentangling ancestry interactions in admixed populations. bioRXiv preprint. DOI: 10.1101/2025.06.30.662316 (ASHG 2024 Reviewer’s Choice; STATGEN 2025 Slides; Code and Data)
2. R. Mandla, Z. Shi, K. Hou, Y. Wang, G. Mies, A.J. Aw, S. Cullina, Penn Medicine Biobank, E. Kenny, E. Atkinson, A.R. Martin and B. Pasaniuc (2025+). Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences. medRXiv preprint. DOI: 10.1101/2025.04.02.25325115
3. 🏋🏻‍♂️ A.J. Aw, J.F. McRae, E. Rahmani & Y.S. Song (2024+). Highly parameterized polygenic scores tend to overfit to population stratification via random effects. bioRXiv preprint. DOI: 10.1101/2024.01.27.577589 (Code and Data, Dashboard)

In Preparation

1. 🏋🏻‍♂️ J.V. Moreno-Mayar, A.J. Aw, Y. Deng, …, G. Kroonen, P. Grebenyuk, D. Meltzer, Y.S. Song, E. Willerslev (2025+). Historical ancient genomics shed light on dynamic Holocene origins of Indigenous Siberians and their languages.

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