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Alan Aw

Postdoctoral Researcher
University of Pennsylvania
nalawanij (at) gmail.com


A 🏋🏻‍♂️ (representing “heavy lifting”) indicates (co-)first authorship. Though, science is a team sport. Maths papers are ordered alphabetically by last name.

Publications

  1. G. Benegas, C. Albors, A.J. Aw, C. Ye, Y.S. Song (2025). A DNA language model based on multi-species alignment predicts the effects of genome-wide variants. Nature Biotechnology. DOI: 10.1038/s41587-024-02511-w (Code and Data, VEP Scores)
  2. 🏋🏻‍♂️ A.J. Aw, J.P. Spence & Y.S. Song (2024). A simple and flexible test of sample exchangeability with applications to statistical genomics. Annals of Applied Statistics 18 (1):858-881. DOI: 10.1214/23-AOAS1817 (Software: flintyR and flintyPy, Code and Data, Tutorials)
  3. 🏋🏻‍♂️ A.J. Aw, L.C. Jin, N.M. Ioannidis & Y.S. Song (2023). The impact of stability considerations on genetic fine-mapping. eLife Reviewed Preprint. DOI: 10.7554/eLife.88039.1 (Shiny App, Code and Data)
  4. 🏋🏻‍♂️ T.C. Zeng, A.J. Aw & M.W. Feldman (2018). Cultural hitchhiking and competition between patrilineal kin groups explain the post-Neolithic Y-chromosome bottleneck. Nature Communications 9 (1): article no. 2077. DOI: 10.1038/s41467-018-04375-6 (Code and Data)
  5. A.J. Aw & N.A. Rosenberg (2018). Bounding measures of genetic similarity and diversity using majorization. Journal of Mathematical Biology 77 (3): 711-737. DOI: 10.1007/s00285-018-1226-x
  6. A.J. Aw & C.Y. Ku (2015). The covering radius problem for sets of 1-factors of the complete uniform hypergraphs. Discrete Mathematics 338 (6):P 875-884. DOI: 10.1016/j.disc.2015.01.014
  7. A.J. Aw (2014). The multicovering radius problem for some types of discrete structures. Designs, Codes and Cryptography 72 (2): 195-209. DOI: 10.1007/s10623-012-9755-6
  8. A.J. Aw (2012). The Turán number and probabilistic combinatorics. The American Mathematical Monthly 119 (6): 510-513. DOI: 10.4169/amer.math.monthly.119.06.510

Preprints / Under Review

  1. 🏋🏻‍♂️ F. Zhou, A.J. Aw, D. Erdmann-Pham, J. Fischer, Y.S. Song (2025+). Robust and adaptive non-parametric tests for detecting general distributional shifts in gene expression. bioRXiv preprint. DOI: 10.1101/2025.03.06.641952 (Software: QRScore)
  2. 🏋🏻‍♂️ A.J. Aw, J.F. McRae, E. Rahmani & Y.S. Song (2024+). Highly parameterized polygenic scores tend to overfit to population stratification via random effects. bioRXiv preprint. DOI: 10.1101/2024.01.27.577589 (Code and Data, Dashboard)

In Preparation

  1. R. Mandla, Z. Shi, K. Hou, Y. Wang, G. Mies, A.J. Aw, I.N. Mathieson, E. Atkinson, A.R. Martin and B. Pasaniuc (2025+). Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences.
  2. 🏋🏻‍♂️ A.J. Aw, R. Mandla, Z. Shi, Penn Medicine Biobank, B. Pasaniuc, I.N. Mathieson (2025+). Gene-ancestry interactions moderate individual causal effects on complex traits in admixed populations. (ASHG Reviewer’s Choice Poster)
  3. 🏋🏻‍♂️ J.V. Moreno-Mayar, A.J. Aw, Y. Deng, …, G. Kroonen, P. Grebenyuk, D. Meltzer, Y.S. Song, E. Willerslev (2025+). Historical ancient genomics shed light on dynamic Holocene origins of Indigenous Siberians and their languages.

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